BENZOIC ACID DERIVATIVE AND PREPARATION THEREOF

NEW MATERIAL:The compound of formula I (R and R are H, lower alkyl or together with adjuacent N form a 5- or 6-membered heterocyclic group; n is 2-4; X is halogen) and its salt. EXAMPLE:2-(N,N-dimethylamino)ethyl 4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy) propoxy]-3-bromobenzoate. USE:Remedy for asth...

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Bibliographic Details
Main Authors MAKI YOSHITAKA, NOHARA AKIRA
Format Patent
LanguageEnglish
Published 17.06.1986
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:NEW MATERIAL:The compound of formula I (R and R are H, lower alkyl or together with adjuacent N form a 5- or 6-membered heterocyclic group; n is 2-4; X is halogen) and its salt. EXAMPLE:2-(N,N-dimethylamino)ethyl 4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy) propoxy]-3-bromobenzoate. USE:Remedy for asthma and anti-inflammatory agent. It has antagonistic activity against the chemotransmitter SRS-A causing the constriction of bronchial smooth muscle, and is useful for the remedy of asthma and hay fever, etc. caused by SRS-A. PREPARATION:The compound of formula I can be prepared by reacting the reactive derivative of the compound of formula II with the reactive derivative of formula II.
Bibliography:Application Number: JP19850213579