THREITOL DERIVATIVE

NEW MATERIAL:The compound of formula I (R is 16-18C straight-chain alkyl). EXAMPLE:1-0-Hexadecyl-2,3-di-0-acetyl-D-threitol-4-phosphorylcholine. USE:Hypotensor, blood platelet coagulant, and their intermediate. PREPARATION:The compound of formula I can be prepared by (1) reducing the compound of for...

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Bibliographic Details
Main Authors OONO MASAJI, FUJITA KAGARI
Format Patent
LanguageEnglish
Published 10.01.1985
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:NEW MATERIAL:The compound of formula I (R is 16-18C straight-chain alkyl). EXAMPLE:1-0-Hexadecyl-2,3-di-0-acetyl-D-threitol-4-phosphorylcholine. USE:Hypotensor, blood platelet coagulant, and their intermediate. PREPARATION:The compound of formula I can be prepared by (1) reducing the compound of formula II with palladium black usually in glacial acetic acid at room temperature for 1-10hr to obtain a dihydroxylated compound, and (2) acetylating the product with e.g. acetic anhydride usually in an organic solvent, if necessary in the presence of a base (e.g. pyridine, triethylamine, etc.).
Bibliography:Application Number: JP19830112526