NOVEL PHYSIOLOGICALLY ACTIVE PROTEIN SUBSTANCE

NEW MATERIAL:A physiologically active protein substance (molecular weight: two groups having 6,300+ or -500mol.wt. and 9,000-13,000mol.wt.; not being decomposed with deoxyribonuclease, ribonuclease, and neuraminidase, and deactivated with a protease such as tripsin, chymotrypsin, etc.). USE:An activ...

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Main Authors SEYA TOMOKO, SATOU SEIJI, FUJIYOSHI NORIO, FUJIWARA KATSUMI, OKABE TETSUO
Format Patent
LanguageEnglish
Published 25.11.1985
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:NEW MATERIAL:A physiologically active protein substance (molecular weight: two groups having 6,300+ or -500mol.wt. and 9,000-13,000mol.wt.; not being decomposed with deoxyribonuclease, ribonuclease, and neuraminidase, and deactivated with a protease such as tripsin, chymotrypsin, etc.). USE:An activator for promoting DNA synthesis. PREPARATION:A human myelogenic leukemia cell [e.g., strain K562-T1 (obtained by training strain K562 for about one year while reducing gradually serum concentration from a medium of ham F10 containing 10% fetal vitular serum), etc.] is cultivated in a medium [e.g., nonprotein medium such as medium of ham F10, etc.], and a protein substance having activity to promote DNA synthesis is obtained from the supernatant liquid of the medium. It promotes multiplication of B cell system having antibody production ability, is expected as an adjuvant, to be applicable for anemia, and to have carcinostatic action, and usable as a remedy for wounds.
Bibliography:Application Number: JP19840092570