BENZOXATHIIN DERIVATIVE, ITS PREPARATION AND USE

NEW MATERIAL:The compound of formula I (R is H or lower alkyl; R is lower alkyl or aralkyl) or its acid addition salt. EXAMPLE:8-( 3-Methylamino-2-hydroxypropoxy )-3,4-dihydro-1,2-benzoxathiin-2,2- dioxide. USE:It has beta-blocking activity, and is useful as a remedy for arrhythmia, stenocardia, and...

Full description

Saved in:
Bibliographic Details
Main Author HORI MIKIO
Format Patent
LanguageEnglish
Published 25.09.1985
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:NEW MATERIAL:The compound of formula I (R is H or lower alkyl; R is lower alkyl or aralkyl) or its acid addition salt. EXAMPLE:8-( 3-Methylamino-2-hydroxypropoxy )-3,4-dihydro-1,2-benzoxathiin-2,2- dioxide. USE:It has beta-blocking activity, and is useful as a remedy for arrhythmia, stenocardia, and hypertension. It has low toxicity and side effect, and long duration. PREPARATION:The compound of formula I can be produced by reacting the novel compound of formula II with the amine of formula R R NH. The reaction is carried out in an alcoholic solvent at room temperature or under heating. The starting compound of formula II can be prepared from o-vaniline or formula III.
Bibliography:Application Number: JP19840044730