PRODUCTION OF M-HYDROXYACETOPHENONE

PURPOSE:To produce the titled compound which is an intermediate for medicines, agricultural chemicals and dyes, etc. industrially and advantageously in short steps, by reacting m-(2-hydroxy-2-propyl)acetophenone with H2O2 in the presence of an acid catalyst, and decomposing the reaction product with...

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Bibliographic Details
Main Authors NAKAMURA MAKOTO, KAI SEIICHI, KOUNO NOBUHARU
Format Patent
LanguageEnglish
Published 16.07.1985
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:PURPOSE:To produce the titled compound which is an intermediate for medicines, agricultural chemicals and dyes, etc. industrially and advantageously in short steps, by reacting m-(2-hydroxy-2-propyl)acetophenone with H2O2 in the presence of an acid catalyst, and decomposing the reaction product with an acid. CONSTITUTION:m-(2-Hydroxy-2-propyl)acetophenone as a raw material compound is reacted with 5-90wt% aqueous hydrogen peroxide in a molar amount of 1- 20 times of that of the raw material compound in the presence of an acid catalyst, e.g. sulfuric acid or hydrochloric acid, at 30-95 deg.C to give m-(2-hydroperoxy- 2-propyl)acetophenone, which is then decomposed with an acid to afford the aimed m-hydroxyacetophenone. The m-(2-hydroxy-2-propyl)acetophenone which is the starting compound is obtained by reacting m-(2-hydroxy-2-propyl)cumene hydroperoxide in the presence of an aqueous solution containing an iron salt, copper salt and a mineral acid.
Bibliography:Application Number: JP19830241600