HEXAPEPTIDE

• Main Authors: TAKAGI HIROSHI, KAWAJIRI SHINICHI, KUBOTA MINORU
• Format: Patent
• Language: English
• Published: 02.07.1985
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

NEW MATERIAL:A compound shown by the formula I . USE:An analgesic. PREPARATION:For example, a compound shown by the formula H-Arg(NO2)- OBzl.2TosOH (Bzl is benzyl; Tos is paratoluenesulfonyl) is dissolved in DMF, reacted with a compound shown by the formula Z(OMe)-Tyr(Bzl)-OTGCP(Me is methyl; TCP is 2,4,5-trichlorophenyl) in the presence of a tertiary amine to give a compound shown by the formula II. This compound is then reacted with trifluoroacetic acid, and reacted with a compound shown by the formula Boc- Arg(NO2)-OH(Boc is t-butyloxycarbonyl) to give a compound shown by the formula III. This compound is further reacted with a compound shown by the formula Z(OMe)-Tyr(Bzl)-OTCP, treated with TFA, and reacted with Boc-Arg (NO2)-OH, ethylchoroformate, etc., to give a compound shown by the formula IV. Finally this compound is reacted with a compound shown by the formula Z (OMe)-Tyr(Bzl)-OTCP, and the protecting group is removed, to give a compound shown by the formula I .