NOVEL PEPTIDE

• Main Authors: HAGIWARA DAIJIROU, HASHIMOTO SHINJI, HENMI KEIJI
• Format: Patent
• Language: English
• Published: 06.06.1984
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

NEW MATERIAL:Fourteen kinds of peptides (salts) such as H-Thr-Lys-Asp-Leu- Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-OH, etc. USE:Immuno-regulating agent. PROCESS:The objective peptide can be prepared, e.g. by (1) charging a benzhydrylamine resin hydrochloride prepared from a styrene-divinylbenzene copolymer in a solid-phase reactor, (2) reacting Boc-Glu(OBzl)-OH (Boc is amino-protecting group; Bzl is benzyl) in the presence of dicyclohexyl carbodiimide, etc., (3) eliminating the amino-protecting group, (3) successively reacting Glu, Val, Val, Glu, Lys, Lys, Glu, Lys, Leu, Asp, Lys and Thr in a simmilar manner after protecting amino group and side chain functional group, and (4) treating with hydrogen fluoride in the presence of anisole, thereby eliminating all the protecting groups and the resin.