INHIBITORY SUBSTANCE FOR BIOSYNTHESIS OF PROSTAGLANDIN

NEW MATERIAL:A compound shown by the formula I (R1 is H, or OCH3; R2 is OH, or OCH3; R3 is H, or represents =O together with R2; R4 and R5 are H, or R4 represents =O together with R5; or R4 and C at the 4-position form a double bond). EXAMPLE:7-(4''-Hydroxy-3''-methoxyphenyl)-1-p...

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Bibliographic Details
Main Author MIKAWA USHIO
Format Patent
LanguageEnglish
Published 06.06.1984
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:NEW MATERIAL:A compound shown by the formula I (R1 is H, or OCH3; R2 is OH, or OCH3; R3 is H, or represents =O together with R2; R4 and R5 are H, or R4 represents =O together with R5; or R4 and C at the 4-position form a double bond). EXAMPLE:7-(4''-Hydroxy-3''-methoxyphenyl)-1-phenyl-3,5-heptadione. USE:An inhibitor for biosynthesis of prostaglandin useful as a drug having antiphlogistic action, antipyretic action, analgesic action, antiallergic action, counteracting action on formaton of thrombus, inhibitory action on aging of blood vessel (prevention of arteriosclerosis), remedying menoxenia, for antihydrophilic diarrhea, etc. as a substance for controlling arachidonic acid cascade. PROCESS:Rhizome of Alpinia officinarum Hance is extracted with methanol, and the extracted solution is fractionated into an n-hexane soluble fraction and a chloroform soluble fraction by a conventional procedure. The chloroform soluble fraction is purified by chromatography using an inhibitory action on prostaglandin synthetase as an index, and it is fractionated to give a compound shown by the formula.
Bibliography:Application Number: JP19820207285