PYRIDAZINONE DERIVATIVE

NEW MATERIAL:A compound shown by the formula I [R1 is H, or lower alkyl; R2 is H, or hydrazinocarbonyl; R3 is H, alkylamino-substituted lower alkyl, lower alkyl N-substituted carbamoyl; X is O, or unsubstituted). EXAMPLE:6-( Phenothiazin-2-yl )-5-methyl-2-n-butylcarbamoyl-4, 5-dihydro-3-( 2H ) pyrid...

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Bibliographic Details
Main Authors KAMIYA JIYOUJI, TANAKA YASUHITO, NISHINA TAKASHI, FUKAZAWA NOBUYUKI, KATAUE ISAO
Format Patent
LanguageEnglish
Published 28.03.1984
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:NEW MATERIAL:A compound shown by the formula I [R1 is H, or lower alkyl; R2 is H, or hydrazinocarbonyl; R3 is H, alkylamino-substituted lower alkyl, lower alkyl N-substituted carbamoyl; X is O, or unsubstituted). EXAMPLE:6-( Phenothiazin-2-yl )-5-methyl-2-n-butylcarbamoyl-4, 5-dihydro-3-( 2H ) pyridazinone. USE:Useful as a drug for circulatory organ system such as antithrombosis, antilipemic agent, etc. PROCESS:A compound shown by the formula II (R4 is H, carboxy, etc.; with the proviso that a case where both are H is omitted) is reacted with hydrazine or its hydrate in a solvent such as methanol, etc. at 0-100 deg.C, to give a compound shown by the formula III.
Bibliography:Application Number: JP19820163124