JPS5943947B

NEW MATERIAL:A N-substituted moranoline derivative of the formula (X is propylene or propenylene group). EXAMPLE:N-Phenylpropylmoranoline. USE:Preventives or remedies for diseases, e.g. diabetes mellitus, or its prodrome, hyperlipemia, arteriosclerosis, corpulence, cardiopathies such as myocardial i...

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Main Authors YAGI MASAHIRO, KURA KOHEI, AOYANAGI YOSHIAKI, YOSHIKUNI YOSHIAKI, SHIRAHASE ICHIRO, MATSUMURA SHINGO, ENOMOTO HIROSHI
Format Patent
LanguageEnglish
Published 25.10.1984
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:NEW MATERIAL:A N-substituted moranoline derivative of the formula (X is propylene or propenylene group). EXAMPLE:N-Phenylpropylmoranoline. USE:Preventives or remedies for diseases, e.g. diabetes mellitus, or its prodrome, hyperlipemia, arteriosclerosis, corpulence, cardiopathies such as myocardial infarction, gastroenteric disorder, such as gastritis, gastric ulcer, or duodenal ulcer, due to hyperglycemia, having hypoglycemic actions. PROCESS:Moranoline is reacted with a reagent, e.g. an aralkyl halide, aralkenyl halide, or aralkylsulfonate, having an active aralkyl or aralkenyl group, in a polar solvent, e.g. water, an alcohol, DMSO, DMF, cellosolve, or glyme, in the presence of a deacidification agent at room temperature or above to give the compound of formula.
Bibliography:Application Number: JP19780053603