(MET(O)8,18)HPTH-(1-34)PEPTIDE

NEW MATERIAL:A peptide of the formula H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met(O)- His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met(O)-Glu-Arg-Val-Glu-Trp-Leu-Arg -Lys- Lys- Leu-Gln-Asp-Val-His-Asn-Phe-OH or a salt thereof. USE:A medicine having reducing action on calcium in urine. PREPARATION:A well-known hPTH-(1-...

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Bibliographic Details
Main Authors OGATA ETSUROU, MORITA KOU, MATSUMOTO TOSHIO, KUZUKI SHIGEO, MATSUNAGA HIROSHI
Format Patent
LanguageEnglish
Published 19.11.1984
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:NEW MATERIAL:A peptide of the formula H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met(O)- His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met(O)-Glu-Arg-Val-Glu-Trp-Leu-Arg -Lys- Lys- Leu-Gln-Asp-Val-His-Asn-Phe-OH or a salt thereof. USE:A medicine having reducing action on calcium in urine. PREPARATION:A well-known hPTH-(1-34)peptide is oxidized with an oxidizing agnet, e.g. hydrogen peroxide, in an aquous solution at room temperature, and water is added thereto to freeze-dry the oxidation product. Thus, the aimed peptide of the formula is obtained.
Bibliography:Application Number: JP19830075607