NOVEL SF-2259 SUBSTANCE AND ITS PREPARATION

• Main Authors: HIDAKA HIDEMASA, TAKIZAWA TOSHIO, SHIYOUMURA TAKASHI, ITOU TATSUO, MATSUHASHI NOBUO, YOSHIDA JIYUNKO
• Format: Patent
• Language: English
• Published: 13.09.1984
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOUNDS OF UNKNOWN CONSTITUTION; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PURPOSE:To prepare the titled substance useful for the prevention and remedy of dental caries, by culturing a microbial strain belonging to Micromonospora genus and capable of producing the titled substance. CONSTITUTION:A microbial strain belonging to Micromonospora genus and capable of producing the novel physiologically active substance, SF-2259, e.g. Micromonospora sp. SF-2259 (FERM-P No.6953), is cultured, and the objective novel physiologically active substance SF-2259 is separated from the cultured product. The substance suppresses the activity of glucosyl transferase produced by Streptococcus mutans, the synthesis of dextran polysaccharide, and the formation of bactrial plague, and accordingly, it is effective to prevent or cure the dental caries.