STABLE VITAMIN K2 AQUEOUS COMPOSITION AND ITS PREPARATION

PURPOSE:The titled composition even to be medicated intravenously, having a long-term stability and low toxicity, obtained by using a mixture prepared by adding sorbitan trioleate to polyoxyethylene hardened castor oil, having a specific HLB value, as a solubilizer for vitamin K2. CONSTITUTION:A mix...

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Bibliographic Details
Main Author YAMANISHI YASUHITO
Format Patent
LanguageEnglish
Published 22.04.1983
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PURPOSE:The titled composition even to be medicated intravenously, having a long-term stability and low toxicity, obtained by using a mixture prepared by adding sorbitan trioleate to polyoxyethylene hardened castor oil, having a specific HLB value, as a solubilizer for vitamin K2. CONSTITUTION:A mixture comprising polyoxyethylene hardened castor oil (non- ionic surface active agent) and sorbitan trioleate, showing a HLB vule of 12.3- 13.7 is used as a solubilizer for vitamin K2. A stable vitamin K2 aqueous composition useful as an injection capable of being medicated intravenously, having a pH of approximately 5.9, comprising preferably (A) 1pts.wt. vitamin K2. (B) 5-13pts.wt. solubilizer, (C) proper pts.wt. inorganic acid substance (pH adjustor), preferably dipotassium hydrogenphosphate, and (D) water (solvent) in an amount to dissolve the components A-C to give total 100pts.vol.
Bibliography:Application Number: JP19810166166