STABLE VITAMIN K2 AQUEOUS COMPOSITION AND ITS PREPARATION

PURPOSE:The titled composition even to be medicated intravenously, having a long-term stability and low toxicity, obtained by using a mixture prepared by adding sorbitan trioleate to polyoxyethylene hardened castor oil, having a specific HLB value, as a solubilizer for vitamin K2. CONSTITUTION:A mix...

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Bibliographic Details
Main Author YAMANISHI YASUHITO
Format Patent
LanguageEnglish
Published 22.04.1983
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Summary:PURPOSE:The titled composition even to be medicated intravenously, having a long-term stability and low toxicity, obtained by using a mixture prepared by adding sorbitan trioleate to polyoxyethylene hardened castor oil, having a specific HLB value, as a solubilizer for vitamin K2. CONSTITUTION:A mixture comprising polyoxyethylene hardened castor oil (non- ionic surface active agent) and sorbitan trioleate, showing a HLB vule of 12.3- 13.7 is used as a solubilizer for vitamin K2. A stable vitamin K2 aqueous composition useful as an injection capable of being medicated intravenously, having a pH of approximately 5.9, comprising preferably (A) 1pts.wt. vitamin K2. (B) 5-13pts.wt. solubilizer, (C) proper pts.wt. inorganic acid substance (pH adjustor), preferably dipotassium hydrogenphosphate, and (D) water (solvent) in an amount to dissolve the components A-C to give total 100pts.vol.
Bibliography:Application Number: JP19810166166