PREPARATION OF 5-ACETAMIDOMETHYL-4-AMINO-2- METHYLPYRIMIDINE

PURPOSE:To prepare the titled compound important as a synthetic intermediate of vitamin B1, in extremely high selectivity, by using a novel 4-alkoxy-1,3- dioxane-5-carbonitrile as a starting material, and reacting with acetamidine. CONSTITUTION:5-Acetamidomethyl-4-amino-2-methylpyrimidine is prepare...

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Bibliographic Details
Main Authors NISHIHIRA KEIGO, FUJII KOUZOU, TANAKA HIDEJI, SAWADA HIROYUKI, YOSHIDA HIROSHI, NAKAI MAMORU
Format Patent
LanguageEnglish
Published 18.04.1983
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:PURPOSE:To prepare the titled compound important as a synthetic intermediate of vitamin B1, in extremely high selectivity, by using a novel 4-alkoxy-1,3- dioxane-5-carbonitrile as a starting material, and reacting with acetamidine. CONSTITUTION:5-Acetamidomethyl-4-amino-2-methylpyrimidine is prepared by reacting a novel 4-alkoxy-1,3-dioxane-5-carbonitrile of formula (R is lower alkyl) (e.g. 4-methoxy-1,3-dioxane-5-carbonitrile) with acetamidine. Since acetamidine is an unstable substance, it is preferable to use in the form of a salt with an inorganic acid. The 4-alkoxy-1,3-dioxane-5-carbonitrile which is a novel compound used as a starting material can be prepared by reacting 3-alkoxy-2- propenenitrile compound with formaldehyde in the presence of an acid catalyst.
Bibliography:Application Number: JP19810162106