PREPARATION OF 2-ALKYL-4-AMINO-5-AMINOMETHYLPYRIMIDINE

PURPOSE:To prepare the titled substance useful as an important synthetic intermediate of vitamin B1 and its analogues, in high yield, by the catalytic reaction of 2-alkyl-4-amino-5-formylpyrimidine with hydrogen and ammonia in the presence of a catalyst. CONSTITUTION:The titled compound is prepared...

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Main Authors OOMORI KIYOSHI, NISHIHIRA KEIGO, FUJII KOUZOU, TANAKA HIDEJI, SAWADA HIROYUKI, YOSHIDA HIROSHI, NAKAI MAMORU, INOUE TERUHIKO
Format Patent
LanguageEnglish
Published 19.08.1983
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:PURPOSE:To prepare the titled substance useful as an important synthetic intermediate of vitamin B1 and its analogues, in high yield, by the catalytic reaction of 2-alkyl-4-amino-5-formylpyrimidine with hydrogen and ammonia in the presence of a catalyst. CONSTITUTION:The titled compound is prepared by the catalytic reaction of 2- alkyl-4-amino-5-formylpyrimidine with hydrogen and ammonia at 0-200 deg.C, preferably at room temperature 120 deg.C in the presence of a reduction catalyst under the hydrogen partial pressure of usually 1-100kg/cm G. The effective catalyst is the VIII-group metal such as Pd, Pt, Rh, Ru, Ni, etc. or a metal such as Cu, Cr, etc. The amount of the catalyst is 0.001-3g-atom, preferably 0.002-2g-atom in terms of metal based on the above raw material. The amounts of H and ammonia are preferably 5-400mol and 4-500mol per 1mol of the raw material, respectively.
Bibliography:Application Number: JP19820022122