NOVEL TRICYCLIC CAGE AMINE COMPOUND

NEW MATERIAL:The novel tricycic cage amine derivative of formula I (A1 is single bond or alkylene chain bonded to 2- or 3-position; R1 is H, alkyl, alkenyl, alkynyl, aralkyl, alkoxycarbonyl, etc.; R2 is H, alkyl, alkenyl, alkynyl, etc.; R1 and R2 may together with adjacent N atom form a 5 or 6-membe...

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Bibliographic Details
Main Authors KATSUBE SUMIMOTO, IGUMA TAKASHI, SUGIE AKIHIKO
Format Patent
LanguageEnglish
Published 10.03.1982
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:NEW MATERIAL:The novel tricycic cage amine derivative of formula I (A1 is single bond or alkylene chain bonded to 2- or 3-position; R1 is H, alkyl, alkenyl, alkynyl, aralkyl, alkoxycarbonyl, etc.; R2 is H, alkyl, alkenyl, alkynyl, etc.; R1 and R2 may together with adjacent N atom form a 5 or 6-membered cyclic amino), and its acid salt. EXAMPLE:5-Oxa-endo-2-amino-twistobrendane. USE:Anti-influenzal agent. PROCESS:The compound of formula I is prepared e.g. by (1) converting cyclopentadiene, etc. to bicyclo [2,2,1] heptene derivative by Diels-Alder reaction, (2) converting the product to an alcohol derivative of formula II (Y is OH, halogen, acylamino, etc.), (3) cyclizing the compound by photo-reaction, and (4) modifying the side chain of the resulting ether compound of formula III.
Bibliography:Application Number: JP19800120517