MODIFIED POLYPEPTIDE

PURPOSE:To provide a chemically, modified polypeptide in which antigenicity is eliminated while retaining the physiological activity of polypeptide at a high level, by subjecting amino groups in the molecule of polypeptide with a group contg. a specified polyethylene glycol residue. CONSTITUTION:Par...

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Bibliographic Details
Main Authors TOKUNAGA KEIKO, UNUMA TSUNEO, HIROSE KATSUMI, YUKIMATSU YOSHIKAZU
Format Patent
LanguageEnglish
Published 26.11.1982
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS BASED THEREON
COMPOSITIONS THEREOF
CULTURE MEDIA
DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
ORGANIC MACROMOLECULAR COMPOUNDS
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
THEIR PREPARATION OR CHEMICAL WORKING-UP
VINEGAR
WINE
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Summary:PURPOSE:To provide a chemically, modified polypeptide in which antigenicity is eliminated while retaining the physiological activity of polypeptide at a high level, by subjecting amino groups in the molecule of polypeptide with a group contg. a specified polyethylene glycol residue. CONSTITUTION:Part or the whle of amino groups in the molecule of polypeptide such as uricase, arginase or insulin is substituted with a group of formulaI (wherein R1 is F, Cl, OH or a group which does not react with the polypeptide; the group of formula II is a polyethylene glycol residue having a number- average MW of 5,000-15,000; R2 is alkyl, an arom. group, alkylcarbonyl, arom. carbonyl, alkylaminocarbonyl, arom. amino carbonyl) to produce a modified polypeptide which is an enzyme having a physiological activity effective in the treatment of patients and in which antigenicity is lowered or completely eliminated while retaining highly the physiological activity of the polypeptide.
Bibliography:Application Number: JP19810077153