NOVEL HAPTENIC ANTIGEN AND ITS PREPARATION

NEW MATERIAL:A haptenic antigen expressed by formulaI(R is immunogenic carrier substance; the terminal carbonyl in[ ]is linked to the amino group which is a part of R; m is an integer 1-3; n is an integer 5-70). EXAMPLE:A combination product of 3 {2 [4-diisopropylamino-2-phenyl-2-(pyridyl)butyramido...

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Main Authors SHIMADA HIDETAKA, HASHIMOTO SEIJI, SHINOZAKI TEIZOU, MATSUNAGA ISAO, WAKABAYASHI KIYOSHIGE, YAMAMOTO REIKO, TAKAMURA KEIICHI
Format Patent
LanguageEnglish
Published 26.11.1982
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TESTING
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Summary:NEW MATERIAL:A haptenic antigen expressed by formulaI(R is immunogenic carrier substance; the terminal carbonyl in[ ]is linked to the amino group which is a part of R; m is an integer 1-3; n is an integer 5-70). EXAMPLE:A combination product of 3 {2 [4-diisopropylamino-2-phenyl-2-(pyridyl)butyramido]ethoxycarbonyl}prop ionic acid with bovine blood serumal albumin. USE:A haptenic antigen for obtaining a specific antigen against the dispyramide (a remedy for arrhythmia). PROCESS:A novel compound expressed by formula II or a reactive derivative thereof is reacted with the amino group of an immunogenic carrier substance, e.g. bovine blood serumal albumin, to give the aimed haptenic antigen expressed by formulaI. The compound expressed by formula II is obtained by reacting a compound expressed by formula III with a lower alkanolamine, and reacting the resultant compound expressed by formula IV with an equimolar amount of succinic anhydride.
Bibliography:Application Number: JP19810074807