CEPHALOSPORIN DERIVATIVE AND ITS PREPARATION

• Format: Patent
• Language: English
• Published: 13.07.1979
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

NEW MATERIAL:Compounds of formula I [R is H, lower alkoxy; R is methyl, acetoxymethyl; R is H, nitrile, carboxyl, -COOR (R is alkyl, aryl)] and their salts. EXAMPLE:7beta-[2-Ethoxycarbonyl-(1,3-diethiolan-2-ylidene)acetamide]-3 -(1-methyl- 1H-tetrazole-5yl)thiomethyl-3-cephem-4-carboxylic acid. USE:Antibacterial agents, having activity inhibiting beta-lactamase and being effective against gram-positive and -negative bacteria. PREPARATION:The reaction of a compound of formula II (R is protected carboxyl group) with a compound of formula III (Y is halogen; R is H, nitrile, -COOR ) in the presence of an acid acceptor in an inert solvent is effected and then protecting groups is eliminated to prepare a compound of formula IV.