NEW PIPERIDINE DERIVATIVE, ITS PRODUCTION AND AGENT FOR CIRCULATORY ORGAN CONTAINING THE DERIVATIVE

• Main Authors: SUZUKI SHIGERU, MANOME YOICHI, KOJO KENTARO, MURATA MUNEKO, GOTO TAKAO
• Format: Patent
• Language: English
• Published: 26.03.1999
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide the subject new compound having strong serotonin 2 receptor antagonistic action and excellent separation from central action and useful for the prevention and treatment of circulatory diseases. SOLUTION: This compound is expressed by formula I (R and R are each, H, a lower alkyl, a lower alkoxy or a halogen; X is O or S; A is CR (CN), the group of formula II, etc.; R is a lower alkyl, an alkenyl, etc.; (n) is 1-4), e.g. α- 1-(2-phenethyl)-4-piperidylidene}benzoxazol-2-ylacetonitrile hydrochloride. The compound of formula III with a compound of the formula; R Y (Y is a halogen) in the presence of a base. The compound of the formula I has strong platelet aggregation suppressing action especially by oral administration and is useful for the prevention and treatment of ischemic cardiopathy such as arrhythmia, heart failure, stenocardia and myocardial infarction, cerebrovascular disorders such as cerebral, infarction and transient ischemic attack, diseases caused by peripheral circulation disorder such as Raynaud disease and Buerger disease, hypertension, etc.