SUBSTITUTED TRICYCLIC COMPOUND

• Main Authors: MCGILL JOHN M III, BASTIAN JOLIE ANNE, SALL DANIEL JON, PHILLIPS MICHAEL L, HITE GARY A, RICHARD JAMES LONCHARICH, MIHELICH EDWARD DAVID, VASILEFF ROBERT THEODORE, MICHAEL ENRICO RICETTO, KINNICK MICHAEL DEAN, SAWYER JASON SCOTT, ANDERSON BENJAMIN A, SCHEVITZ RICHARD W, HARN NANCY KAY, BACH NICHOLAS J, HARPER RICHARD WALTZ, LIN HO-SHEN, MORIN JOHN MICHAEL JR
• Format: Patent
• Language: English
• Published: 24.11.1999
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To obtain a new compound useful for inhibiting the release of a fatty acid mediated by sPLA2 for a state such as in a septic shock. SOLUTION: This substituted tricyclic compound is 9-[(phenyl)methyl]-5- carbamoylcarbazol-4-yl} oxyacetic acid, or its pharmaceutically permissible...