SUBSTITUTED TRICYCLIC COMPOUND
PROBLEM TO BE SOLVED: To obtain a new compound useful for inhibiting the release of a fatty acid mediated by sPLA2 for a state such as in a septic shock. SOLUTION: This substituted tricyclic compound is 9-[(phenyl)methyl]-5- carbamoylcarbazol-4-yl} oxyacetic acid, or its pharmaceutically permissible...
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Main Authors | , , , , , , , , , , , , , , , , , |
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Format | Patent |
Language | English |
Published |
24.11.1999
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Edition | 6 |
Subjects | |
Online Access | Get full text |
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Summary: | PROBLEM TO BE SOLVED: To obtain a new compound useful for inhibiting the release of a fatty acid mediated by sPLA2 for a state such as in a septic shock. SOLUTION: This substituted tricyclic compound is 9-[(phenyl)methyl]-5- carbamoylcarbazol-4-yl} oxyacetic acid, or its pharmaceutically permissible racemic form, solvated compound, tautomer, optical isomer, prodrug derivative or salt, e.g. a compound of formula I [Z is cyclohexene or phenyl; R is a 5-20C alkyl, an alkenyl or the like; R is a non-disturbing substituent having 1-3 f; R is NHNH2 , NH2 or the like; R ' is OH, phenyl or the like; R ' is a non-disturbing substituent, a (substituted) carbon ring group or the like], etc. Further, in order to obtain the compound of the formula, it is preferable to obtain through treating a suitably substituted nitrobenzen of formula II by a reducing agent such as hydrogen at preferably a room temperature in the presence of Pd/C. |
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Bibliography: | Application Number: JP19990109629 |