GENE ENCODING PLATELET PRODUCTION STIMULATING FACTOR

• Main Authors: MATSUMOTO SHUNICHIRO, URASAKI TETSUYA, YAMAJI NOBORU, KITAMURA KOKI, YANO SHINYA, SAKABA NANA, NAKADA SUSUMU, MASUYASU YASUHIKO
• Format: Patent
• Language: English
• Published: 24.11.1999
• Edition: 6
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To obtain a DNA capable of mass-producing a uniform platelet production stimulating factor and useful for the treatment of diseases, etc., accompanied by thrombocytopenia by encoding a protein containing a specific amino acid sequence. SOLUTION: This DNA is capable of encoding a protein containing an amino acid sequence from the 22nd to the 286th residues or the 1st to the 286th residues. A transformed cell such as Escherichia coli transformed with a recombinant vector containing the DNA is preferably cultured to produce the protein.