PRODUCTION OF 2-MERCAPTOTHIAZOLE

PROBLEM TO BE SOLVED: To obtain the subject compound useful as an intermediate for producing medicines and agrochemicals in a good yield by adding a specific dithiocarbamic acid salt solution to a chloroacetaldehyde solution in the presence of an acid to react the compounds with each other, while in...

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Main Authors IWASE NORIAKI, HIRAKAWA TAKAFUMI, MITARU KATSUHIKO, HARADA KATSUMASA, MATSUSHITA AKIO, NAKAMURA TAKU, IKUNO KEN
Format Patent
LanguageEnglish
Published 13.07.1999
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:PROBLEM TO BE SOLVED: To obtain the subject compound useful as an intermediate for producing medicines and agrochemicals in a good yield by adding a specific dithiocarbamic acid salt solution to a chloroacetaldehyde solution in the presence of an acid to react the compounds with each other, while inhibiting the by- production of impurities. SOLUTION: This method for producing a 2-mercaptothiazole comprises adding (C) a dithiocarbamic acid salt of the formula (M is a cation) (for example, dithiocarbamic acid ammonium salt) to (B) a chloroacetaldehyde solution in a solvent such as water in the presence of (A) an acid such as hydrochloric acid preferably at about 20-35 deg.C, and further reacting the compounds with each other preferably at 50-80 deg.C for 2-10 hr. The components A and C are preferably used in amounts of 0.9-2.5 moles and 0.9-3.0 moles, respectively, per mole of the chloroacetaldehyde of component B.
Bibliography:Application Number: JP19970359791