VITRONECTIN RECEPTOR ANTAGONIST, ITS PRODUCTION AND ITS USE

PROBLEM TO BE SOLVED: To obtain a new compound useful as a vitronectin receptor antagonist used as an agent for inhibiting the bone resorption by osteoclasts, an agent for inhibiting the growth or metastasis of tumors or an anti-inflammatory agent and further used for treating and preventing cardiov...

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Main Authors MCDOWELL ROBERT DR, PEYMAN ANUSCHIRWAN, KNOLLE JOCHEN DR, STILZ HANS ULRICH DR, WEHNER VOLKMAR DR, LEFRANCOIS JEAN-MICHEL, CARNIATO DENIS DR, RUXER JEAN-MARIE DR, GADEK THOMAS RICHARD DR
Format Patent
LanguageEnglish
Published 02.06.1999
Edition6
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Summary:PROBLEM TO BE SOLVED: To obtain a new compound useful as a vitronectin receptor antagonist used as an agent for inhibiting the bone resorption by osteoclasts, an agent for inhibiting the growth or metastasis of tumors or an anti-inflammatory agent and further used for treating and preventing cardiovascular diseases, neuropathy, retinopathy or the like. SOLUTION: The compound of the formula: A-B-D-E-F-G [G is A1 or the like; A1 is R R N-C(=NR )NR C(O) or the like; B is a direct bond or the like; D and F are each a direct bond or the like; E is a template selected from a series of fibrinogen receptor antagonists; G is a group of the formula; R and R are each H or the like; R to R are each H or the like; R is C(O)R or the like; R is OH or the like; (q) and (p) are each 0 or 1], The wherein F is C(O)NR , is obtained, for example, by condensing a compound of the formula: A-B-D-E-M (M is a hydroxycarbonyl or the like) with a compound of the formula: HNR -G.
Bibliography:Application Number: JP19970365529