TYPE A MONOAMINE OXIDASE INHIBITOR

PROBLEM TO BE SOLVED: To obtain the subject inhibitor having excellent type A monoamine oxidase-inhibiting action and exhibiting therapeutic or preventive effects on nervous diseases, especially depression. SOLUTION: This inhibitor contains an isoxazole derivative of formula I [R is a 5 to 6-membere...

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Bibliographic Details
Main Authors KOZUKA MASAO, KOJIMA KOICHI, SAKAI JUNICHI, KANEKO TSUGIO, SAFUKU NAOZUMI, YOSHIMI KENJI
Format Patent
LanguageEnglish
Published 25.05.1999
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To obtain the subject inhibitor having excellent type A monoamine oxidase-inhibiting action and exhibiting therapeutic or preventive effects on nervous diseases, especially depression. SOLUTION: This inhibitor contains an isoxazole derivative of formula I [R is a 5 to 6-membered aromatic heterocycle having one or two hetero atoms selected from nitrogen, oxygen or 6-14C aryl; R is hydrogen, a halogen or the like; R is amino, a mono-1-6C alkylamine or the like; X is oxygen or sulfur; (n) is 2-6] or its salt as an active ingredient. 3-(2-Aminoethoxy)5-phenylisoxazole or the like is preferable as the compound of formula I. The compound of formula I is obtained by halogenating a compound of formula II, reacting the product with a compound of the formula HX-(CH2 )n R a (R a is a protected amino, a protected mono-1-6C alkylamino or the like), and as necessary, deprotecting the reaction product.
Bibliography:Application Number: JP19980238220