TRIFLUOROMETHYLPYRIMIDINE DERIVATIVE HAVING HYPOGLYCEMIC ACTION AND ITS PRODUCTION

PROBLEM TO BE SOLVED: To produce a new compound, having strong hypoglycemic actions and useful as a therapeutic agent for diabetes and complications thereof. SOLUTION: This compound is represented by formula I (R is a substituted phenyl, naphthalene which can be substituted with a lower alkyl or a s...

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Main Authors NOMURA MASAHIRO, UCHIKI HIDEJI, TSUNODA MASAKI, MURAKAMI KOJI, AMADA JUNICHIRO, AWANO KATSUYA
Format Patent
LanguageEnglish
Published 10.03.1998
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To produce a new compound, having strong hypoglycemic actions and useful as a therapeutic agent for diabetes and complications thereof. SOLUTION: This compound is represented by formula I (R is a substituted phenyl, naphthalene which can be substituted with a lower alkyl or a substitutable 5- or 6-heterocyclic ring; R and R are each H or a lower alkyl; A is a lower alkoxy or =O; B is H, a lower alkyl, a lower alkoxy, etc.; either one of dotted line parts is a single bond and the other is a double bond), e.g. 5-[(1,3-benzodioxol-5-yl)methyl]-2-methylthio-6-trifluoromethyl-4(3H)- pyrimidinone. The compound represented by formula I is produced by reacting a β-keto ester derivative represented by formula II (R is a lower alkyl) with a compound or a thiourea represented by formula III (R is H, a lower alkylthio or a lower alkyl) in a solvent (e.g. methanol) at ambient temperature to the refluxing temperature of the solvent.
Bibliography:Application Number: JP19960241404