CARRIER FOR ADSORBENT USED FOR DIRECT BLOOD PERFUSION AND ITS GRAIN SIZE REDUCTION METHOD

• Main Authors: KOBAYASHI AKIRA, TAKADA SATORU
• Format: Patent
• Language: English
• Published: 13.01.1998
• Edition: 6
• Subjects: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR RELEVANT APPARATUS; TRANSPORTING

PROBLEM TO BE SOLVED: To reduce the grain size of a carrier for direct blood perfusion while maintaining excellent blood passability by coupling sulfated polysaccharides and/or their salts with a water-insoluble carrier. SOLUTION: This carrier for an adsorbent is formed by coupling the sulfated polysaccharides and/or their salts, for example, heparin, dextran sulfate and/or its potassium salt and sodium salt with the water-insoluble carrier. The sulfated polysaccharides and/or their salts which have the ultimate viscosity of 0.005 to 0.5dl/g are preferable for suppressing the adhesion of the blood cells. About 0.007 to 0.4dl/g is more preferable for efficient execution of immobilization. Further, the sulfur content of the sulfated polysaccharides and/or their salts is preferably specified to 5 to 22wt.% for suppressing the adhesion of the blood cells. Further, the setting of the content to about 8 to 22wt.% is preferable for blood anticoagulation. The amt. of the coupling to the carrier is preferably specified to 0.02 to 200mg per 1ml carrier for suppressing the adhesion of the blood cells.