BENZOXAZOLE-BASED COMPOUND

PROBLEM TO BE SOLVED: To obtain the subject new compound useful as an antiinflammatory agent, an anti-rheumatic and an antiasthmatic agent, existing in a culture product of a strain of a certain species, having inhibitory action on ELAM-1 adhesion. SOLUTION: The compounds are shown by formula I (R i...

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Bibliographic Details
Main Authors YAMAGUCHI AKIE, NAKAO TORU, ANDO TSUTOMU, SANADA KAYO, SUGAWARA TAKAKO
Format Patent
LanguageEnglish
Published 17.02.1998
Edition6
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:PROBLEM TO BE SOLVED: To obtain the subject new compound useful as an antiinflammatory agent, an anti-rheumatic and an antiasthmatic agent, existing in a culture product of a strain of a certain species, having inhibitory action on ELAM-1 adhesion. SOLUTION: The compounds are shown by formula I (R is H or methoxy) and formula II. The compounds are obtained by culturing Microtetraspora spiralis TA-0294 (FERM P-15,757), a newly separated strain from the natural world in a medium containing various nutritive substances under an aerobic condition, centrifuging or filtering the culture product to give a culture filtrate, adsorbing the filtrate, eluting with an organic solvent and purifying. The compound of formula I has the following properties. Appearance; yellow powder. Melting point: 126-130 deg.C. Molecular weight: 416. Molecular formula: C20 H20 N2 O8 . HRFAB mass spectrum: 455.0856. FAB mass spectrum: m/z 417(M+H)<+> . Specific rotatory power: +82.7 deg. (c=0.09 methanol). Solubility: soluble in chloroform, methanol, etc., insoluble in n-hexane and benzene. Distinction of basicity, acidity and neutrality: neutral.
Bibliography:Application Number: JP19960208094