NEW ARYLACETAMIDE

PROBLEM TO BE SOLVED: To obtain a new compound useful for suppressing atherosclerosis and coronary arterial cardiopathy. SOLUTION: This new compound is represented by formula I (R and R together form phenyl, pyridyl ring, etc.; R and R together form phenyl ring, a 4- to an 8-membered cycloalkene, et...

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Main Authors DENZER DIRK DR, GRUETZMANN RUDI DR, NIELSCH ULRICH DR, BISCHOFF HILMAR DR, ECKENBERG PETER DR, MUELLER ULRICH DR
Format Patent
LanguageEnglish
Published 10.02.1998
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To obtain a new compound useful for suppressing atherosclerosis and coronary arterial cardiopathy. SOLUTION: This new compound is represented by formula I (R and R together form phenyl, pyridyl ring, etc.; R and R together form phenyl ring, a 4- to an 8-membered cycloalkene, etc.; R is H, a 1-12C alkyl, etc.; R is a 3-8C cycloalkyl; R is a 3-8C cycloalkyl, phenyl, etc.; D and E together contain CH and form a 4- or an 8-membered carbocyclic ring), e.g. 2-(S)-2- cyclopentyl-2-[4-(2,4-dimethyl-α-carbolin-9-yl)-methylphenyl]acetic acid N-(1-phenyl- ethen-1-yl)amide. The compound represented by formula I is obtained by starting from a carboxylic acid represented by formula II, producing an acid chloride and reacting the resultant acid chloride with an amine represented by the formula HNR R suitably in the presence of a base and/or an assistant in an inert solvent.
Bibliography:Application Number: JP19970110047