MEDICINE CONTAINING AMINO ALCOHOL DERIVATIVE AND ABNORMAL PROLIFEROUS DISEASE THERAPEUTIC DRUG

PROBLEM TO BE SOLVED: To obtain the subject remedy which aims at attempting secession from abnormal proliferous states by inducing differentiation of cells abnormally proliferating at undifferentiated states to differentiate to final differentiated cells having the fixed life span and is useful for...

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Bibliographic Details
Main Authors INOKUCHI JINICHI, JINBO MASAYUKI, YAMAGISHI KIWAMU, NOJIRI HISAO, YAMANA HIDEAKI
Format Patent
LanguageEnglish
Published 22.12.1998
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To obtain the subject remedy which aims at attempting secession from abnormal proliferous states by inducing differentiation of cells abnormally proliferating at undifferentiated states to differentiate to final differentiated cells having the fixed life span and is useful for treating cancer and the like by formulating a specific amyl alcohol derivative thereto. SOLUTION: The objective medicine is obtained by formulating an amyl alcohol derivative of the formula (* is an asymmetric carbon; R is an aryl; R is a cyclic amino; R is H or an acyl; P is an alkyl, an aralkyloxycarbonyl or the like), obtained by treating an optically active N-protective-2- aminoalkandiol in a solvent containing pyridine to mesylate and treating the resultant product with an amine in an organic solvent, or its pharmaceutically permissible salt [e.g. (1R,2R)-2-benzyloxycarbonylamino-3-pyrrolidino-1-phenyl-1- propanol].
Bibliography:Application Number: JP19970163543