HEPARINOID HOMPOLYMER OR COPOLYMER, AND ITS PRODUCTION AND USE

• Main Authors: BROCK ACHIM, WULFF GUENTER, BELLMANN SUSANNE, ANDERS CHRISTINE DR
• Format: Patent
• Language: English
• Published: 08.12.1998
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES THEREOF; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC CHEMISTRY; ORGANIC MACROMOLECULAR COMPOUNDS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

PROBLEM TO BE SOLVED: To obtain the subject new compound useful for medical products, e.g. cardiac valves, catheters, autoscopes, drainage tubes, which are in contact with the blood. SOLUTION: This compound is a heparinoid homopolymer or copolymer having a repetition unit shown by formula I (R is H or methyl; R is a crosslinking element; and A is sulfated polyol, polyamine, (poly)amine(poly)ol or the like), preferably a repetition unit shown by formula II (R is O or NH; R is H or SO3 -Na<+> , at least one of R 's being SO3 -Na<+> ; and (n) is 4 or 5), e.g. O-sulfated-1-hydroxy-1-desoxy-1-(4-vinylphenyl)-D-gluco(C-manno)-penti tol. The monomer shown by formula II is obtained by acetalizing the hydroxy group in, e.g. D-glucono-1,5-lactone, converting the resultant (cyclo)lactoned into the (open-chain)methyl ester by the aid of methanol, reducing the resultant isomer mixture, cleaving the carbon chain by the aid of an oxidant, and introducing vinyl functional group by the Grignard reaction.