PRODUCTION OF CLOSED VESICLE

PROBLEM TO BE SOLVED: To prepare a closed vesicle, used for a medicine such as an antitumor agent or an agent, etc., for diagnosis and having high safety by rehydrating a closed vesicle comprising a dehydrated micellar particle or a dehydrated amphiphilic micellar double layer under specific conditi...

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Bibliographic Details
Main Authors NAGAIKE KAZUHIRO, TAGAWA TOSHIAKI, HOSOKAWA SEIKO
Format Patent
LanguageEnglish
Published 03.02.1998
Edition6
Subjects
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:PROBLEM TO BE SOLVED: To prepare a closed vesicle, used for a medicine such as an antitumor agent or an agent, etc., for diagnosis and having high safety by rehydrating a closed vesicle comprising a dehydrated micellar particle or a dehydrated amphiphilic micellar double layer under specific conditions. SOLUTION: This closed vesicle is prepared by rehydrating a closed vesicle comprising a dehydrated micellar particle or a dehydrated amphiphilic micellar double layer under low-temperature conditions, especially 10-0 deg.C when rehydrating the closed vesicle with a rehydrating solution. The closed vesicle can be applied to the one in which a medicine or an agent for diagnosis is introduced. The closed vesicle can especially be applied to an antitumor agent such as adriamycin, daunomycin or vinblastine and a pharmaceutically permissible salt and a derivative thereof as a medicine. A liposome can be cited as the closed vesicle. Furthermore, the liposome to which an antibody or a polyethylene glycol or both are applied is preferred.
Bibliography:Application Number: JP19970092119