2-PHENYL-2-(2'-PIPERIDINYLIDENE)ACETIC ACID ESTER DERIVATIVE AND ITS PRODUCTION

• Main Authors: KIYOFUJI NOBUO, KUMOBAYASHI HIDENORI, SOTOGUCHI TSUKASA, YUASA YOSHIFUMI, NISHIKAWA TAKENOBU, MIURA TAKASHI
• Format: Patent
• Language: English
• Published: 20.10.1998
• Edition: 6
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

PROBLEM TO BE SOLVED: To obtain the subject new compound that is useful as a key intermediate for an antidepressant simply and economically. SOLUTION: This compound is represented by formula I (R is H, a 1-4C alkyl, a lower alkoxy; R is a 1-4C alkyl; R is H, an amino group-protecting group), typically 2-phenyl-2-(2'-piperidinylidene)acetic methyl ester. The objective compound is prepared by cycling a 7-(N-substituted amino)-3-oxo-2- phenylheptanoic ester derivative of formula II (R is a protecting group for amino group) such as methyl 7-(N-benzyl-oxycarbonyl)amino-3-oxo-2- phenylheptanoate by heating the compound at room temperature to 100 deg.C in the presence of a base such as potassium carbonate for 2-18 hours.