TESTING METHOD FOR MUTATION AND ANTI-MUTATION USING HIGH-SENSITIVITY MOUSE

PROBLEM TO BE SOLVED: To examine mutagenicity, anti-mutagenicity, carcinogenesis, and anti- carcinogenesis by using a high-sensitivity MS/Ae mouse. SOLUTION: A substance to be tested is given to an MS/Ae mouse. The sister chromatids exchange frequency of the MS/Ae mouse is checked to examine the mut...

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Bibliographic Details
Main Authors NUMATA MASAHIRO, SUDOU SHIZUYO, NAKADE KOJI, HIGASHIKUNI MASAHIKO
Format Patent
LanguageEnglish
Published 13.10.1998
Edition6
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:PROBLEM TO BE SOLVED: To examine mutagenicity, anti-mutagenicity, carcinogenesis, and anti- carcinogenesis by using a high-sensitivity MS/Ae mouse. SOLUTION: A substance to be tested is given to an MS/Ae mouse. The sister chromatids exchange frequency of the MS/Ae mouse is checked to examine the mutagenicity of the substance to be tested. Also the micronucleus- inducing frequency of the MS/Ae mouse is checked to examine the anti- mutagenicity of the substance to be tested. Also, the lung adenoma-inducing frequency and the Ms/Ae mouse is checked to examine the carcinogenesis and the anti-carciongenesis of the substance to be tested. The MS/Ae mouse is highly sensitive to a micronucleus test, a sister chromatids exchange test, and also shows a high sensitivity to a carcinogenesis agent, this easy screening of a mutagenicity substance, an anti-mutagenicity substance, a carcinogensis substance, and an anti-carcinogenesis substance is made possible.
Bibliography:Application Number: JP19970078623