METHOD FOR IMPROVING YIELD OF IMMUNE ANTIBODY IN PREVENTIVE VACCINATION OF ANIMAL AND MAN

PROBLEM TO BE SOLVED: To enable the enhancement of immune response to vaccine for domestic animal and man by using a specific adjuvant. SOLUTION: The adjuvant to be used in this process contains a glycopeptide GMDP (N-acetyl-glucosaminyl-N-acetylmuramyl-L-alanyl-Disoglutamine) and a colloidal soluti...

Full description

Saved in:
Bibliographic Details
Main Author GRUBHOFER NIKOLAUS DR
Format Patent
LanguageEnglish
Published 27.01.1998
Edition6
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:PROBLEM TO BE SOLVED: To enable the enhancement of immune response to vaccine for domestic animal and man by using a specific adjuvant. SOLUTION: The adjuvant to be used in this process contains a glycopeptide GMDP (N-acetyl-glucosaminyl-N-acetylmuramyl-L-alanyl-Disoglutamine) and a colloidal solution of a solid lipid substance. The solid lipid substance is a biodecomposable substance containing a lipid having a melting point of >=37 deg.C. Examples of the substance are triglceride, lecithin, D,L-α-tocopheryl acetate, etc. A colloidal solution stable in the presence of emulsifier and dispersing agent is formed from the substance. The colloidal solution contains solid liquid particles having diameter of <0.2μm and is asepticized by filtration. The administration dose of glycopeptide is 10μg/kg-body weight. The adjuvant is effective for suppressing the formation of granuloma of gout, man, etc., by the synergistic interaction of GMDP and lipid.
Bibliography:Application Number: JP19970084634