HETEROARYL-SUBSTITUTED PROPIONYL GUANIDINE DERIVATIVE

PROBLEM TO BE SOLVED: To obtain a the subject compound having a heteroaryl group substituted at 2 position, having good Na<+> /H<-> exchanger inhibiting action and useful as a preventive, therapeutic or diagnostic agent for diseases in which Na<+> /H<-> exchanger participates...

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Bibliographic Details
Main Authors OKAZAKI TOSHIO, KIKUCHI KAZUMI, TAKANASHI MASAHIRO, KAKU HIDETAKA
Format Patent
LanguageEnglish
Published 08.09.1998
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To obtain a the subject compound having a heteroaryl group substituted at 2 position, having good Na<+> /H<-> exchanger inhibiting action and useful as a preventive, therapeutic or diagnostic agent for diseases in which Na<+> /H<-> exchanger participates. SOLUTION: This compound is represented by formula I [A ring is a (substituted)5-6-membered heteroaryl; B ring is a (substituted)aryl; R and R are each H or a (fluorine-substituted)lower alkyl], e.g. N-[3-phenyl-2-(3-pyridyl) propionyl]guanidine. The compound is preferably obtained by reacting 3-aryl-2- heteroarylpropanoic acid represented by formula II or its reactive derivative with guanidine.
Bibliography:Application Number: JP19970042420