PRODUCTION OF OPTICALLY ACTIVE 2-PHENYL-2-(2'-PIPERIDINYL) ACETIC ACID ESTER DERIVATIVE

PROBLEM TO BE SOLVED: To obtain the subject compound useful e.g. as a key intermediate for antidepressant on an industrial scale at a low cost by asymmetrically hydrogenating a 2-phenyl-2-(2'-piperidinylidene)acetic acid ester derivative in the presence of a group VIII transition metal complex....

Full description

Saved in:
Bibliographic Details
Main Authors KIYOFUJI NOBUO, KUMOBAYASHI HIDENORI, SOTOGUCHI TSUKASA, YUASA YOSHIFUMI, NISHIKAWA TAKENOBU, MIURA TAKASHI
Format Patent
LanguageEnglish
Published 02.09.1998
Edition6
Subjects
APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS
GENERAL METHODS OF ORGANIC CHEMISTRY
GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC
GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
THEIR RELEVANT APPARATUS
TRANSPORTING
Online AccessGet full text

Cover

More Information
Summary:PROBLEM TO BE SOLVED: To obtain the subject compound useful e.g. as a key intermediate for antidepressant on an industrial scale at a low cost by asymmetrically hydrogenating a 2-phenyl-2-(2'-piperidinylidene)acetic acid ester derivative in the presence of a group VIII transition metal complex. SOLUTION: The objective optically active compound derivative expressed by formula III (* is asymmetric carbon atom) and useful e.g. as a key intermediate for antidepressant is produced by the asymmetric hydrogenation of a 2- phenyl-2-(2'-piperidinylidene)acetic acid ester derivative of formula I (R is H, a 1-4C lower alkyl or a 1-4C lower alkoxy; R is a 1-4C alkyl; R is H or an amino-protecting group) in the presence of a group VIII transition metal complex of formula II (M is ruthenium iridium or rhodium; L is an optically active phosphine ligand; X is H, a halogen or a carboxylic acid derivative residue; Q is ethylene, 1,5-octadiene, benzene, etc.; Y is a halogen ion, ClO4 <-> , BF4 <-> , etc.; (m), (n) and (s) are each 1 or 2; (q) is 0, 1 or 2), etc.
Bibliography:Application Number: JP19970072570