HETEROCYCLIC-CONDENSED PYRIDINES

• Main Authors: MUELLER-GLIEMANN MATTHIAS DR, SCHMIDT DELF DR, RORUFU ANGAABAUAA, BRANDES ARNDT DR, SCHMECK CARSTEN DR, LOEGERS MICHAEL DR, BISCHOFF HILMAR DR, BREMM KLAUS-DIETER DR, SCHMIDT GUNTER DR, SCHUHMACHER JOACHIM DR
• Format: Patent
• Language: English
• Published: 23.06.1998
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To obtain the subject compound useful for treatment and prevention of heterolipidemia or atherosclerosis. SOLUTION: This compound is expressed by formula I [A is an 6-10C aryl; D is formula II or III (R and R are each a 3-8C cycloalkyl; X is an alkylene of 8C or less and the like; R is H and a halogen; R is H, a halogen, an azide, etc.); E is a 3-8C cycloalkyl and the like; R and R are combined to form an 6C alkylene chain], its salt and the N-oxide, e.g. 3-ethyl 5-methyl 6- cyclopentyl-4-(4-fluorophenyl)-2-oxo-1,2,3,4-tetrahydropyridine-3,5-di carboxylate. The compound is obtained by initially introducing the substituent D into the compound of formula IV by Grignard reaction or Wittig reaction using organic metal reagents in an inactive solvent followed by suitably converting or introducing substituents illustrated as A, E and/or R and R by ordinary processes.