5ALPHA-REDUCTASE INHIBITOR, BISISOFLAVONE

PROBLEM TO BE SOLVED: To obtain a novel bisisoflavone as a 5 α-reductase inhibitor which has the inhibitory action against 5 α-reductase and is useful as a preventive and therapeutic agent for prostatic hyperplasia. SOLUTION: A-758491 of the formula or its salt. The compound of the formula has the f...

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Bibliographic Details
Main Authors HOSHINO EMIKO, SUGANO MICHIHIRO, OGURA YOKO, TAKAMATSU YASUYUKI, HAMADA TAKAKAZU, ENOKIDA RYUZO
Format Patent
LanguageEnglish
Published 11.03.1997
Edition6
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:PROBLEM TO BE SOLVED: To obtain a novel bisisoflavone as a 5 α-reductase inhibitor which has the inhibitory action against 5 α-reductase and is useful as a preventive and therapeutic agent for prostatic hyperplasia. SOLUTION: A-758491 of the formula or its salt. The compound of the formula has the following physical and chemical properties: properties: pale yellow powder; molecular formula: C30 H18 O10 (determined by high-resolution mass spectroscopy); molecular weight: 538 (mass spectrometry); solubility: soluble in methanol, ethanol, acetone, dimethyl sulfoxide and benzene, insoluble in water, chloroform, diethyl ether, ethyl acetate; color reaction: positive to sulfuric acid and iodine. The compound of the formula is obtained by aerobically culturing SANK 60695 strain.
Bibliography:Application Number: JP19950224944