PRODUCTION OF IMIDAZOLE DERIVATIVE

PROBLEM TO BE SOLVED: To carry out a reduction, etc., in the number of steps and produce the subject compound capable of manifesting strong inhibiting activities against calmodulins and useful as an improving agent for cerebropathy on a large scale by diazotizing a specific compound and then treatin...

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Bibliographic Details
Main Authors MAKINO TORU, ITOU MIKIHIRO, MIYADERA AKIHIKO
Format Patent
LanguageEnglish
Published 25.11.1997
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To carry out a reduction, etc., in the number of steps and produce the subject compound capable of manifesting strong inhibiting activities against calmodulins and useful as an improving agent for cerebropathy on a large scale by diazotizing a specific compound and then treating the resultant compound with a reducing agent. SOLUTION: A compound of formula I (R and R are each a 1-6C alkyl, a 1-6C alkoxyl, trifluoromethyl, 2,2,2-trifluoroethyl, trifluoromethoxy, 2,2,2- trifluoroethoxy, a 1-6C alkylthio, etc.) or its salt is diazotized and the resultant compound is then treated with a reducing agent to afford a compound of formula II, concretely 5,6-dimethoxy-1H-imidazole-3-acetic acid. The compound of formula II is preferably further condensed in the presence of a dehydrating agent by using an alcohol or reacted with a diazoalkane to provide a compound of formula III (R is a 1-6C alkyl), which is preferably further reduced.
Bibliography:Application Number: JP19960119218