MEDICINAL COMPOSITION COMPRISING TERFENADINE

PROBLEM TO BE SOLVED: To prepare a medicinal composition for peroral administration, comprising terfenadine, useful as a therapeutic agent for allergic diseases without containing a surfactant, excellent in preservation for a long period and good in elution properties. SOLUTION: This medicinal compo...

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Bibliographic Details
Main Authors MASUDA HIROTAKA, KUMAGAI EIJI, OISHI KATSUTOSHI, IIJIMA MASANORI
Format Patent
LanguageEnglish
Published 07.10.1997
Edition6
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To prepare a medicinal composition for peroral administration, comprising terfenadine, useful as a therapeutic agent for allergic diseases without containing a surfactant, excellent in preservation for a long period and good in elution properties. SOLUTION: This medicinal composition comprises 20-35wt.% terfenadine and 8-22wt.% magnesium carbonate and is further suitably blended with a therapeutically inert ingredient such as an excipient, a binder, a disintegrator or a lubricant therewith without containing a surfactant therein. The composition is prepared as a tablet, a capsule, a powder, a granule, etc., preferably the tablet according to a conventional method. In the case of the tablet containing 60mg terfenadine which is an active substance in one tablet, the peroral administration of the tablet is preferably daily carried out twice in the solid medicinal composition.
Bibliography:Application Number: JP19960103531