THIOUREA DERIVATIVE OF PLAUNOTOL

PROBLEM TO BE SOLVED: To obtain thiourea derivative of plaunotol having excellent antiulcer action and antibacterial action against Hericobacter pyroli and useful for therapy and/or prevention of ulcerative disease. SOLUTION: This compound is a thiourea derivative of plaunotol or its pharmacological...

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Bibliographic Details
Main Authors UTSUI YUKIO, KOGA TETSUFUMI, AKIYAMA TOSHIYUKI, TABATA KEIICHI, KADOKAWA HIROSHI
Format Patent
LanguageEnglish
Published 24.06.1997
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To obtain thiourea derivative of plaunotol having excellent antiulcer action and antibacterial action against Hericobacter pyroli and useful for therapy and/or prevention of ulcerative disease. SOLUTION: This compound is a thiourea derivative of plaunotol or its pharmacologically permissible salt of formula I [R and R are each hydroxyl, amino, a group of the formula, NH-CS-NH-X-R (R is a 1-6C alkyl, a 3-10C cycloalkyl, etc.; X is a single bond, a 1-6C alkene), etc.; (n) is an integer of 0-2], e.g. plaunotol-1-ethylthiourea. The compound of formula I is obtained by e.g. reacting a compound of formula II with a compound of formula III (R is a 1-6C alkyl, etc.) in an inert solvent in the presence of 6-10C triarylphosphine (preferably triphenylphosphine), etc.
Bibliography:Application Number: JP19950326667