PRODUCTION OF HALOGENATED CYCLOPROPANE DERIVATIVE

• Main Authors: IKETANI TAKANOBU, EHATA TSUTOMU, WAKITA RYUHEI, SASAKI MIKIO, AKIBA TOSHIFUMI
• Format: Patent
• Language: English
• Published: 13.05.1997
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

PROBLEM TO BE SOLVED: To stereo-selectively and efficiently obtain the subject optically active compound useful as an intermediate for producing new synthetic quinolone antibacterial agents by reacting a vinylidene halide with a diazo compound in the presence of a specific catalyst. SOLUTION: (B) A compound of the formula: CH2 =CXF (X is Cl, Br, I) is reacted with (B) a compound of the formula: N2 HCOR [R is a 1-10C alkyloxy (substituted with a halogen), an aralkyloxy comprising a (substituted)aryl and a 1-10C alkyloxy, a (substituted) aryloxy, a (halogenated aryloxy, a (halogenated) 1-10C alkylthio, an aralkylthio comprising a (substituted) aryl and a 1-10C alkylthio, amino, etc.; the substituent of the substituted aryl is a halogen, a 1-10C (halogenated) alkyl, etc.,] to preferentially produce the compound of the formula wherein the steric configuration of the 1-position is the S-configuration.