CEPHEM COMPOUND, ITS PRODUCTION AND ANTIMICROBIAL COMPOSITION

PURPOSE: To obtain the subject new compound, a specific cephem compound, having a wide range of antimicrobial activity, presenting excellent antimicrobial action on methicillin-resistant Staphylococcus aureus(MRSA) and Pseudomonas bacteria, thus useful as e.g. an antimlcrobial agent. CONSTITUTION: T...

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Bibliographic Details
Main Authors ISHIKAWA TOMOYASU, MIYAKE AKIO, OKONOGI KENJI
Format Patent
LanguageEnglish
Published 24.12.1996
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PURPOSE: To obtain the subject new compound, a specific cephem compound, having a wide range of antimicrobial activity, presenting excellent antimicrobial action on methicillin-resistant Staphylococcus aureus(MRSA) and Pseudomonas bacteria, thus useful as e.g. an antimlcrobial agent. CONSTITUTION: This new cephem compound (ester, salt) is expressed by formula I [R is a (protected) amino; R is H car a group linked via a carbon atom; A<+> is a substituted group of e.g. formula II (B is a six-membered aromatic heterocycle with one or two heteroatoms being N; R is a hydrocarbon)]. This compound has excellent antimicrobial effect on a wide range of Gram-positive and Gramnegative bacteria, esp. Staphylococcus aureus, MRSA and Pseudomonas bacteria, etc., therefore being useful as e.g. an antimicrobial agent. This compound is obtained by reaction of a 7-amino-3-cephem-4-carboxylic acid compound of formula III with a 1,2,4-thiadiazol-3-yl-3-iminoacetic acid derivative of formula IV.
Bibliography:Application Number: JP19960012998