AMINO ACID DERIVATIVE AND ITS PRODUCTION

PURPOSE: To produce the subject derivative, having a specific structure and storing inhibiting activities against resin and useful for treating and preventing hypertension, cardiac insufficiency, renopathy, etc., especially a therapeutic agent for dementia. CONSTITUTION: A compound of formula I [R i...

Full description

Saved in:
Bibliographic Details
Main Authors WATANABE SHINYA, NEYA MASAHIRO, HASHIMOTO SHINJI, HENMI KEIJI, MARUSAWA HIROSHI
Format Patent
LanguageEnglish
Published 29.10.1996
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:PURPOSE: To produce the subject derivative, having a specific structure and storing inhibiting activities against resin and useful for treating and preventing hypertension, cardiac insufficiency, renopathy, etc., especially a therapeutic agent for dementia. CONSTITUTION: A compound of formula I [R is (thio)morpholinocarbonyl, hexahydro-1H-azepin-1-y1-carbonyl, octahydroazocin-1-ylcarbonyl, etc.; R and R are each a lower alkyl, R is a (substituted) lower alkyl; X is a lower alkylene; Y is a single bond or NR (R is a lower alkyl); Y is NH or O], e.g. (2S, 3S)-2-[Nα-[N-[N-methyl-N- 2-(N-morpholinocarbonyl-N-methylamino) ethyl}aminocarbonyl]-L-phenylalanyl]-Nα-methyl-L-histidyl]amino-1-chclohexyl-3- hydroxy-5-methylhexane. This compound is obtained by reacting a compound of formula II (R is H or an N-protecting group) with a compound of formula III.
Bibliography:Application Number: JP19960010000