3-ACETOXY-4-METHOXYIODOBENZENE AND ITS PRODUCTION

• Main Authors: KASHIMA MIKITO, AKIBA YOSHIICHI, NODA YUMIKI
• Format: Patent
• Language: English
• Published: 17.09.1996
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

PURPOSE: To provide 3-acetoxy-4-methoxyiodobenzene useful as a starting raw material for intermediates used in producing medicines and agrochemicals. CONSTITUTION: This 3-acetoxy-4-methoxyiodobenzene is expressed by the formula. The compound is obtained by reacting 2-acetoxyanisole with iodine and nitrogen dioxide, as necessary, in the presence of an acidic catalyst (e.g. a silica gel supporting molybdic acid) at ambient temperature to 100 deg.C for 10min to 10hr. The reaction is carried out by using the iodine in a molar amount of 1/2 based on the 2-acetoxyanisole and the NO2 in a molar amount of 1.5-5 times based on the raw material. The compound of the formula is used as a raw material to afford a 3-acetoxy-4-methoxy-substituted aromatic compound utilizable as an intermediate for various medicines and agrochemicals at a good economical efficiency according to the simple reaction.