3-ACETOXY-4-METHOXYIODOBENZENE AND ITS PRODUCTION

PURPOSE: To provide 3-acetoxy-4-methoxyiodobenzene useful as a starting raw material for intermediates used in producing medicines and agrochemicals. CONSTITUTION: This 3-acetoxy-4-methoxyiodobenzene is expressed by the formula. The compound is obtained by reacting 2-acetoxyanisole with iodine and n...

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Bibliographic Details
Main Authors KASHIMA MIKITO, AKIBA YOSHIICHI, NODA YUMIKI
Format Patent
LanguageEnglish
Published 17.09.1996
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:PURPOSE: To provide 3-acetoxy-4-methoxyiodobenzene useful as a starting raw material for intermediates used in producing medicines and agrochemicals. CONSTITUTION: This 3-acetoxy-4-methoxyiodobenzene is expressed by the formula. The compound is obtained by reacting 2-acetoxyanisole with iodine and nitrogen dioxide, as necessary, in the presence of an acidic catalyst (e.g. a silica gel supporting molybdic acid) at ambient temperature to 100 deg.C for 10min to 10hr. The reaction is carried out by using the iodine in a molar amount of 1/2 based on the 2-acetoxyanisole and the NO2 in a molar amount of 1.5-5 times based on the raw material. The compound of the formula is used as a raw material to afford a 3-acetoxy-4-methoxy-substituted aromatic compound utilizable as an intermediate for various medicines and agrochemicals at a good economical efficiency according to the simple reaction.
Bibliography:Application Number: JP19950043737