PRODUCTION OF ALPHA-CYANO-TERT-BUTYLACETIC ACID LOWER ALKYL ESTER

PURPOSE: To obtain the subject ester useful as a production intermediate for plant blight controlling agents in high efficiency by reacting a specific lower alkyl ester with methylmagnesium halide in the presence of a copper catalyst. CONSTITUTION: This ester is produced by reacting (A) a lower alky...

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Bibliographic Details
Main Authors YAMADA YOSHIMI, ENOMOTO MASAYUKI, MAGARA OSAMU
Format Patent
LanguageEnglish
Published 13.08.1996
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:PURPOSE: To obtain the subject ester useful as a production intermediate for plant blight controlling agents in high efficiency by reacting a specific lower alkyl ester with methylmagnesium halide in the presence of a copper catalyst. CONSTITUTION: This ester is produced by reacting (A) a lower alkyl ester of 2-cyano-3-methyl-2-butenoic acid (e.g. 2-cyano-3-methyl-2-butenoic acid methyl ester) with (B) a methylmagnesium halide (e.g. methylmagnesium chloride) in the presence of (C) a copper catalyst (preferably CuCl, CuBr, CuI, CuCl2 , CuBr2 or CuI2 ) e.g. in THF solvent at 10-60 deg.C for 0.5-10hr. The component A is preferably produced by reacting acetone with a cyanoacetic acid compound (e.g. methyl cyanoacetate) in the presence of a catalyst (e.g. a substituted aniline) using n-hexane as a main solvent.
Bibliography:Application Number: JP19950277552