PRODUCTION OF TRIAZOLE DERIVATIVE AND ITS INTERMEDIATE

PURPOSE:To simply obtain the subject compound useful as an intermediate raw material for insecticides or acaricides in good yield by reacting a hydrazone derivative with a cyanobenzoic acid ester in the presence of ferric chloride and then reducing the resultant compound. CONSTITUTION:This method fo...

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Bibliographic Details
Main Authors SAKAKIBARA YOSHIFUSA, UMETSU KAZUTO
Format Patent
LanguageEnglish
Published 16.01.1996
Edition6
Subjects
APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:PURPOSE:To simply obtain the subject compound useful as an intermediate raw material for insecticides or acaricides in good yield by reacting a hydrazone derivative with a cyanobenzoic acid ester in the presence of ferric chloride and then reducing the resultant compound. CONSTITUTION:This method for producing a triazole derivative of formula IV [X and Y are each a halogen; R is a lower alkyl] is to react a compound of formula I (R is a lower alkyl) with a compound of formula II (R is a lower alkyl) in the presence of ferric chloride in a suitable solvent (e.g. chlorobenzene) at 90-180 deg.C, provide a compound of formula III and then react the resultant compound of formula III with a reducing agent (e.g. sodium borohydride) in a solvent (e.g. butanol) at 20-80 deg.C. The compound of formula III is new and 3-(2-chloro-6-fluorophenyl)-5-(4-methoxycarbonylphenyl)-1-methyl-1H-1, 2,4-triazole is exemplified. The compound of formula IV is new and 3-(2-chloro-6- fluorophenyl)-5-(4-methoxycarbonylphenyl)-1-methyl-1H-1,2,4-triazole is exemplified.
Bibliography:Application Number: JP19940167423